Retrotranslocation: Endoplasmic Reticulum’s Junk Disposal Mechanism
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چکیده
منابع مشابه
4SCIENTIFIC REVIEW Retrotranslocation: Endoplasmic Reticulum’s Junk Disposal Mechanism
The primary structure of polypeptides is converted to their final tertiary and quaternary structure by sequential maturation steps, and the endoplasmic reticulum (ER) provides the environment for the polypeptides to attain their proper 3-dimensional architecture. Proteins that misfold or fail to oligomerize with their partners (Chen et al., 1998; Wileman et al., 1990) are quickly degraded, as u...
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The plant toxin ricin is transported retrogradely from the cell surface to the endoplasmic reticulum (ER) from where the enzymatically active part is retrotranslocated to the cytosol, presumably by the same mechanism as used by misfolded proteins. The ER degradation enhancing alpha-mannosidase I-like protein, EDEM, is responsible for directing aberrant proteins for ER-associated protein degrada...
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ژورنال
عنوان ژورنال: Einstein Journal of Biology and Medicine
سال: 2016
ISSN: 1559-5498,1559-5501
DOI: 10.23861/ejbm200421444